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研究提供肠道细菌与类风湿性关节炎发展有关的新证据_我的网站

一 |     BALTIMORE -- In the wake of a shooting that left five people injured during homecoming festivities, Morgan State University leaders announced Tuesday they plan to build a wall around most of the northeast Baltimore campus and station security personnel at entrances and exits.The wall would extend existing barriers by about 8,000 feet (2,400 meters) to encircle 90% of campus and effectively “eliminate unfettered access,” university President David Wilson said during a campus town hall.“We’re doing this, let me be clear, not to keep out our neighbors and our community writ large; we are doing it to keep out the bad actors,” Wilson told an auditorium filled with students, faculty and staff of the historically Black university.After the shooting the night of Oct. 3 following a coronation ceremony for this year’s Mister and Miss Morgan State, university leaders canceled classes and homecoming activities for the remainder of the week. They’re now grappling with how to keep students safe as gun violence becomes an ever-growing threat in American schools.During Tuesday’s town hall, Wilson and others faced a litany of questions from students and staff demanding to know what more could have been done to prevent the shooting. Students were walking from an auditorium to the campus student center, where a coronation ball was scheduled to start, when the gunfire erupted.The campus was placed on lockdown and students were told to shelter in place because police initially thought there was an active shooter threat. No arrests have been made, but Baltimore police have released surveillance images of persons of interest and asked the public for help identifying them. Police said they believe the violence stemmed from a dispute and involved two shooters.They said the five victims, including four Morgan State students, likely were not intended targets. All the victims were released from local hospitals last week.University officials said significant security upgrades were underway before the shooting, but they’re now moving forward with more urgency. In addition to the wall, other potential upgrades include installing more metal detectors in campus buildings, exploring weapons detection technology, increasing police patrols and building additional security guard booths. Wilson said the anticipated total cost is more than $22 million.Previous Morgan State homecoming celebrations have also been subject to violence. In October 2022, a young man was shot during what officials called an unsanctioned homecoming after-party on campus, and the year before, a freshman was arrested and charged with shooting his classmate over homecoming weekend.The university, which has about 9,000 students, was founded in 1867 with an initial mission of training men for ministry, according to its website. It moved to its current site in northeast Baltimore in 1917 and was purchased by the state of Maryland in 1939 as it aimed to provide more opportunities for Black citizens. Wilson began his presentation Tuesday with reminders of the university’s mission and core values. He said he spoke with the injured students earlier that day and one of them had a message for the university community: “Today may look grim but tomorrow is bright.”Wilson also promised to reschedule the homecoming ball that was thwarted by gunfire.。    类风湿性关节炎被广泛认为是一种多因素的疾病。这意味着没有一个单一的基因或环境暴露是对其发展的唯一责任。相反，可能需要一系列的因素来触发与该疾病相关的自身免疫行为。越来越多的证据表明，肠道微生物组在该疾病的发生中起着作用。事实上，一种特定的细菌菌株已经成为近年来许多研究的焦点。Prevotella copri通常不被认为是一种有害的肠道细菌菌株。它可以在大多数人的微生物组中找到，甚至与高纤维、低脂肪的饮食有关。但在过去十年中，一些研究发现类风湿性关节炎与Prevotella copri的异常水平之间存在关联。这项新的研究专门研究了一种免疫抗体的血液水平，这种抗体是针对Prevotella copri所表达的一种特定蛋白质而产生的。

二 | 研究人员不仅对预先存在的类风湿性关节炎患者是否对这种特殊的细菌蛋白表现出过度的免疫反应感兴趣，而且他们还观察了处于疾病早期阶段的人群，以及被归类为发展该疾病高风险的群体。分析技术显示，与健康对照组相比，那些患有类风湿性关节炎的人确实显示出更高的抗体水平。

三 | 但更重要的是，与对照组相比，那些处于该疾病高风险的人也显示出更高的抗体水平。而且，研究表明一种可能的因果关系，那些已经确立的类风湿关节炎患者与那些处于疾病最早阶段的人相比显示出更高的抗体水平。当然，这些证据还远不是确定的，仍然存在严重的问题。虽然针对这种细菌蛋白的免疫活动增加与类风湿性关节炎之间可能存在关联，但这并不一定意味着这种关系会推动疾病的发展。尽管如此，2017年的一项研究已经假设了这种特殊的Prevotella copri的蛋白质如何可能合理地触发自身免疫活动，导致关节炎的发生。但这仍然是令人难以置信的推测，新研究的通讯作者Jennifer Seifert说，这些发现需要做更多的工作，以更好地了解肠道细菌和类风湿性关节炎（RA）之间的任何潜在关系。

四 | Seifert说：“我们的希望是，这些发现可以帮助进一步阐明细菌共生体在有患RA风险的人和RA患者中的复杂病因作用，从而可以开发出有针对性的疗法，目的是提供更好的治疗，并最终预防该疾病。”这项新研究发表在《关节炎与风湿病学》上。

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